Multi-Tumor, Cell Line & Normal Tissue Studies
Tissue Micro Arrays are ideally suited for further validation of data regarding individual genes with a particular clinical relevance detected by cDNA array analysis. Molecular epidemiology is an important feature for the characterization of a new drug target.
Most molecular abnormalities occur in substantially less than 50% of samples of any individual tumor entity but are present in many different tumor types. Information collected from published literature is often too inconsistent to be practically useful. The main reasons for such discrepancies are methodological and assessment variations between different studies.
TriStar's high density Multi-Tumor array comprises over 3000 individual donor samples from over 120 different cancers. This unique array TMA enables a rapid evaluation of therapeutic targets and forms the basis further cancer-specific prognosis studies.
TriStar's high-density normal tissue array consists of 608 normal tissues from 76 different tissue categories. For each tissue category 8 tissues from 8 different donors are included in the TMA. The high number of 8 donors per tissue was selected to increase the likelihood that all cell types occurring in a tissue category are present on at least on tissue sample. A high number of different donors also reduce the risk of false data due to inappropriate fixation of one or several samples.
For optimal comparability of the data, normal tissue arrays and multi tumor arrays are analyzed together in one experiment.
TriStar's cell line array consists of 140 formalin fixed tumor cell lines (including the NCI 60). This array can be screened simultaneously with the multi tumor and normal arrays for obtaining comprehensive data.
New Arrays
- Hormone refractory prostate cancers
- Prostate cancer bone metastases
- NSCLC primary & matched distant metastases
- Pancreatic cancer primary & matched metastases
- Alzheimer's disease
Contract Research Services
- Large scale multi-tumor (>3500 donor samples) & normal human tissue (>600 donor samples) analysis
- Large scale tumor prognosis analysis
- Large-scale analysis of primary tumors and matched metastases
- GLP tissue cross reactivity studies (human, cynomolgus monkey, rat)
- Gene amplification prognosis studies by FISH
- Pharmacological screening services (cell based assays)
- Cardiotoxicity screening of compounds using EHT (engineered heart tissues)