TriStar Tissue Micro Arrays (TMAs) a tool for the high-throughput analysis of vert large numbers of tissue speciments.

High Throughput Tissue Analysis

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Traditional tissue analysis in a slide-by-slide manner is slow, expensive and difficult to standardize. In addition, precious specimens, such as tissue samples from clinical studies, are usually exhausted after a few analyses. The Tissue Micro Array (TMA) technology overcomes these shortcomings as it allows the simultaneous analysis of thousands of tissue samples in a single experiment.

Virtually all types of in situ analyses applicable to traditional 'large' tissue sections can also be applied to TMA sections, including Immunohistochemistry (IHC), Fluorescence in-situ hybridization (FISH) and RNA in-situ hybridization (ISH).

Our large-scale (>4100 donor) Multi-Tumor and Normal arrays provide valuable information on target expression in over 120 cancers and 76 human normal tissues. Cancer specific prognosis arrays (1500 – 2800 donors per cancer type) relate target expression/amplification to histological sub-types, prognosis, progression, treatment, response (RECIST) and other molecular markers. A recent study by FISH using our 2200-donor breast cancer prognosis array linked ESR1 gene amplification to early stage cancers and predicted Tamoxifen response better than existing IHC tests.