Large-Scale Analysis of Target Epidemiology in Normal & Diseased Tissues
Projects aim at a full characterization of the expression of a target protein in normal and neoplastic human tissues. In addition, associations with tumor phenotype and prognosis are searched for in tumor entities with relevant fraction of "target positivity".
These studies are optimal for early target evaluation. They provide a comprehensive understanding of normal tissue target expression and help secure important intellectual property in relevant cancer types as well as "niche tumors". These studies may also constitute a basis for the necessary development of diagnostic tools paralleling drug development.
Projects typically consist of 3 stages:
- Stage 1 Immunohistochemistry protocol development
- Stage 2 Normal tissue and tumor tissue analysis
- Stage 3 Additional cancer-specific analyses based on results of prognosis, metastases, treatment outcome etc.
New Arrays
- Hormone refractory prostate cancers
- Prostate cancer bone metastases
- NSCLC primary & matched distant metastases
- Pancreatic cancer primary & matched metastases
- Alzheimer's disease
Contract Research Services
- Large scale multi-tumor (>3500 donor samples) & normal human tissue (>600 donor samples) analysis
- Large scale tumor prognosis analysis
- Large-scale analysis of primary tumors and matched metastases
- GLP tissue cross reactivity studies (human, cynomolgus monkey, rat)
- Gene amplification prognosis studies by FISH
- Pharmacological screening services (cell based assays)
- Cardiotoxicity screening of compounds using EHT (engineered heart tissues)