Cancer Stem Cells for Drug Discovery
Please click here to refer to our Corporate Presentation for additional details.
TriStar offers the following unique screening platforms using Cancer Stem Cells:
- Largest collection of Cancer Stem Cells available for drug and target discovery
- Robust and well characterized cells that reproducibly recapitulate cellular hierarchies in vitro and patient tumor histology in vivo
- Validated high throughput in vitro screening assays and in vivo models (subcutaneous and orthotopic)
- Clinical annotation of all CSC samples and growing preclinical database (work in progress: mRNA, miR, phospho-proteomics, sequence data)
- p53, K-Ras, Pten, Smad4, EGFR, PI3KCA, MLH-1, B-Raf, MSH-6 status
- miR expression data are available for colon, glioblastoma and melanoma CSCs
New Arrays Click here for product lists
- Normal Tissue Array 96
- Multi Tumor Tissue Array 880
- Human Cancer Stem Cell (CSC) cytoinclusion array with matched CSC generated xenografts
- Breast cancers primary & paired distant metastases
- Triple negative breast cancer with follow up information
- Breast cancers with trastuzumab treatment data
- Breast cancer prognosis array 600
- Colon cancer progression array
- Colon cancer Stage II-III with KRAS data
- Colon cancer Stage IV with KRAS data
- Colon cancer with bevacizumab treatment information
- Colon cancer prognosis array
- Prostate cancer heterogeneity array
- Prostate cancer progression array 370
- Hormone refractory prostate cancers
- Prostate cancer prognosis array
- Small cell lung cancer (SCLC)
- Lung cancer prognosis array 400 with treatment information
- Pancreatic cancer primary & matched mets
- Multiple Myeloma 60
- Non-Hodgkin's Lymphoma High Grade 152
- Non-Hodgkin's Lymphoma Low Grade 71
32 normal human tissues, 3 donors each
50 donor samples each of lung adenocarcinoma,
lung squamous,lung undifferentiated,SCLC, breast lobular,
breast ductal, prostate, colon, NHL, head & neck, pancreatic, esophageal adenocarcinoma, esophageal squamous, bladder, kidney, melanoma mets, liver, ovarian
Cytospins of multiple human cancer stem cell lines of breast, colon, lung, glioblastoma & melanoma Xenografts generated from the same lines of breast, colon, lung & melanoma
35 primary tumors, 35 paired distant mets
Triple negative breast cancer with follow up information including treatment & response
40 breast cancers with follow up data including trastuzumab responders & non-responders
600 breast cancers with follow-up information
50 low grade adenoma, 50 high grade adenoma, 50 pT2, 50 pT3, 50 nodal mets, 50 liver mets, 10 normals
40 CRC with KRAS data, including mutations & wild type
40 CRC with KRAS data, including mutations & wild type
23 CRC with follow up information including bevacizumab treatment (metastatic & adjuvant) & response, 4 normals
300 colon cancers with follow-up information, with KRAS data incl mutations, treatment information
50 donors, one core each from 8 different primary tumor blocks per donor
Prostate cancer progression array 370 donors
50 HR prostate cancers
500 prostate cancers with 10 yr follow up information
30 donor samples SCLC
400 NSCLC with follow up information
30 pancreatic cancers with paired PT mets
60 multiple myeloma specimens
162 specimens of high grade NHL
69 specimens of low grade NHL