Analysis of Metastases
One of the concerns in the field of targeted therapy is that the primary tumor is removed and examined for a target while the tumor that remains in the patient (metastases) is actually treated. Studies that confirm a similar target alteration in metastases as in the primary tumor are therefore important.
The following specialized tissue arrays are available for comparative primary tumor vs. metastases contract research studies only:
Breast cancer nodal metastasis heterogeneity analysis
Array description: 196 primary tumors of metastatic cancers, three different paired nodal metastases from these tumors, and 196 nodal negative primary cancers
Breast cancer nodal metastasis analysis
Array description: 208 primary tumors and their corresponding metastases
Breast cancer distant metastasis heterogeneity analysis
Array description:1-15 different hematogeneous metastases from the primary tumor located in different organs. This TMA contains 754 different metastases from 160 different patients.
Lung cancer nodal metastasis analysis
Array description: About 250 metastases (mostly nodal) from patients of which the primary tumor is included on lung cancer prognosis array (Ref item 69560347 in the prognosis arrays section)
Colon cancer nodal metastasis analysis
Array description: 200 primary tumors and corresponding lymph node metastasis
The following tissue arrays are available for either transfer or contract research studies:
- 69572265 Breast paired nodal metastases
- 69572275 Breast paired distant metastases
- 79562477 Breast cancer bone metastases array
- 79562478 Colon cancer liver metastases array
- 79562479 Colon cancer paired nodal metastases
- 79562475 Prostate cancer bone metastases array
- 79562480 Prostate cancer paired nodal metastases
- 79562476 NSCLC bone metastases array
- 69571074 NSCLC primary & matched distant metastases
- 79562482 Pancreatic cancer primary & matched mets
New Arrays
- Hormone refractory prostate cancers
- Prostate cancer bone metastases
- NSCLC primary & matched distant metastases
- Pancreatic cancer primary & matched metastases
- Alzheimer's disease
Contract Research Services
- Large scale multi-tumor (>3500 donor samples) & normal human tissue (>600 donor samples) analysis
- Large scale tumor prognosis analysis
- Large-scale analysis of primary tumors and matched metastases
- GLP tissue cross reactivity studies (human, cynomolgus monkey, rat)
- Gene amplification prognosis studies by FISH
- Pharmacological screening services (cell based assays)
- Cardiotoxicity screening of compounds using EHT (engineered heart tissues)